COMPARATIVE RELATIVE BIOAVAILABILITY STUDIES OF SIX BRANDS OF OFLOXACIN MARKETED
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
This study was aimed at assessing the comparative bioavailability of six brands of ofloxacin marketed in Zaria. Comparative bioavailability studies of six brands of ofloxacin marketed in Zaria was successfully conducted. Quality assessment was conducted on the randomly selected six brands of ofloxacin marketed in Zaria. Identification test, assay, weight variation, friability, disintegration time and dissolution rate were determined according to BP 2009. Cheap, simple and accurate U. V. Spectrophotometry method for analysis of ofloxacin in GAA from saliva sample at 295nm was developed and validated based on ICH guideline. Calibration curve was constructed within the range of 3-18µg/ml and validated. The developed method was then employed in the comparative bioavailability studies of six brands of ofloxacin with a washout period of one week. All the brands were found to have the labeled active ingredient. The six brands passed the assay as they were within the accepted range of 99.8-102%. Weight variation was conducted and all the brands passed as their percentage deviations were less than 5%. Similarly all the brands passed the friability except Brand E with more than 1% friability. Disintegration test reveals that all the brands disintegrate in less than 15minutes and all the brands passed the dissolution rate as more than 85% of the active ingredient was released in 30 minutes. The percentage recovery of the developed method was within the accepted range of 98 - 102%. Calibration curve was linear within the range of 3-18µg/ml as the correlation co-efficient was 0.998. The regression equation was y= 0.092x + 0.008. All the brands were well tolerated by the subjects as no adverse effects were reported. The mean Cmax (µg/ml) of brands B, C, E and F were found to be significantly vi (p≥0.05) different from that of the brand A (innovator) while brand D was not significantly (p≥0.05) different (16.66 ± 1.41, 11.7 ± 1.83, 9.82 ± 0.67, 16.25 ± 2.54, 15.35 ± 1.43 and 11.99 ± 0.37 for brand A, B, C, D, E, and F respectively). The mean tmax (hr) of brand C and D were found to be statistically similar (p≥0.05) with that of the innovator while that of brand B, E and F were significantly (p≥0.05) different from that of the innovator (3.5 ± 0.2, 4.0 ± 1.83, 3.5 ± 0.61, 4.5 ± 0.61, 2 ± 0.45 and 2.5 ± 0.22 for brand A, B, C, D, E, and F respectively). For AUC0-8 (µg/ml.h), the values of brands B and D were found to be statistically similar (p≥0.05) with that of the innovator while the values of brands C, E and F were significantly (p≥0.05) different from that of the innovator (72.68 ± 3.58, 56.53 ± 13.26, 43.24 ± 4.25, 100.40 ± 16.01, 92.74 ± 6.75 and 28.17 ± 0.62 for brand A, B, C, D, E, and F respectively). The elimination half life (t1/2 (h)) of brands B and C were statistically similar (p≥0.05) with that of the innovator while brands D, E and F half life values were significantly (p≥0.05) different from that of the innovator (3.08 ± 0.11, 2.89 ± 0.27, 3.01 ± 0.09, 4.27 ± 0.02, 4.23 ± 0.09 and 1.63 ± 0.02 for brand A, B, C, D, E, and F respectively). Brand D was found to be comparatively bioavailable with the innovator. Therefore, it could be used in preference to the innovator due to its cheap price compared to the innovator. Brand B, C, E and F were not comparatively bioavailable as both the rate and extent of absorption were significantly different at p≥0.05 level of significance
Related Project Materials
INFLUENCE OF PARENTAL DISCIPLINE ON EMOTIONAL ADJUSTMENT OF SECONDARY SCHOOL STUDENTS
BACKGROUND OF THE STUDY
Discipline has been defined as a set of rules and regulations, rewards and puni...
EFFECTS OF VITELLARIA PARADOXA LEAF DIETS ON GROWTH AND NUTRITIONAL CONTENTS OF CIRINA FORDA (LEPIDOPTERA: SATURNIIDAE)
ABSTRACT The current challenge of food security has called for exploitation of natural product, with potential nutritional and therapeutic characte...
LOCAL GOVERNMENT A PLATFORM FOR POLITICAL PARTICIPATION
Abstract
This project work centers on Local Government: A plat form for political participation.&n...
A Hybrid Adjacency and Time-Based Data Structure for Analysis of Temporal Networks
Background
Related Work I begin with background information on ways for representing temporal networks and data structures for storing (s...
THE IMPLICATION OF UNEMPLOYMENT ON THE SOCIO ECONOMIC DEVELOPMENT OF NIGERIA (A CASE STUDY OF EGBEMA LOCAL GOVERNMENT AREA)
Background of the Study
Unemployment which is now the talk of the day has a lot of implications on the Nigeria social an...
KNOWLEDGE AND ATTITUDE OF EARLY CHILDHOOD CARE EDUCATION STUDENTS TOWARDS THE STUDY OF EARLY CHILD EDUCATION AS A COURSE
ABSTRACT
This study examined child labour in Edo State with focus on Benin City. This was examined on their everyday act...
DEVELOPMENT OF AN INTERNET PROTOCOL TRACEBACK SCHEME FOR DENIAL OF SERVICE ATTACK SOURCE DETECTION
ABSTRACT
This study presents the development of an Internet Protocol (IP) traceback scheme for the detection of a denial of service (DoS)...
CONSTRUCTION OF MICROCONTROLLER BASED VEHICLE SPEED ALARM.
ABSTRACT
The project is based on Construction of microcontroller vehicle speed alarm system which automatically warns the driver by activ...
IMPACT OF ICT ON STUDENTS ACADEMIC PERFORMANCE IN SECONDARY SCHOOLS
ABSTRACT
This study investigates the impact of Information and Communication Technology (ICT) on academic performa...
INVESTIGATING THE BENEFITS OF EARLY CHILDHOOD DRAMA THERAPY ON EMOTIONAL REGULATION
ABSTRACT: Investigating the benefits of early childhood drama therapy on e...
